Primer preactivation of peptidoglycan polymerases |
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Authors: | Wang Tsung-Shing Andrew Lupoli Tania J Sumida Yuto Tsukamoto Hirokazu Wu Yihui Rebets Yuriy Kahne Daniel E Walker Suzanne |
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Institution: | Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. |
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Abstract: | Peptidoglycan glycosyltransferases are highly conserved bacterial enzymes that catalyze glycan strand polymerization to build the cell wall. Because the cell wall is essential for bacterial cell survival, these glycosyltransferases are potential antibiotic targets, but a detailed understanding of their mechanisms is lacking. Here we show that a synthetic peptidoglycan fragment that mimics the elongating polymer chain activates peptidoglycan glycosyltransferases by bypassing the rate-limiting initiation step. |
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