| 草酸单乙酯三尖杉碱酯的合成及其在三尖杉酯类生物碱合成中的应用 |
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| 引用本文： | 刘兴平,王永铿,李绍白,潘鑫复,李裕林,黄文魁.草酸单乙酯三尖杉碱酯的合成及其在三尖杉酯类生物碱合成中的应用[J].高等学校化学学报,1988,9(9):912. |
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| 作者姓名： | 刘兴平 王永铿 李绍白 潘鑫复 李裕林 黄文魁 |
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| 作者单位： | 兰州大学有机化学研究所 |
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| 摘 要： | 用醇钠催化的酯交换方法合成了草酸单乙酯三尖杉碱酯(4),并用4和格氏试剂反应,得到合成三尖杉酯类生物碱的关键中间体α-酮酰基三尖杉碱(2),简化了已报道的一些三尖杉酯类生物碱的合成方法。
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| 关 键 词： | 草酸单乙酯三尖杉碱酯 &alpha -酮酰 三尖杉碱 |
| 收稿时间： | 1987-03-13 |
The Synthesis of Ethyl Cephalotaxinyl Oxalate and Its Application in the Synthesis of Cephalotaxus Ester Alkaloids |
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| Liu Xingping,Wang Yongkeng. Li Shaobai,Pan Xinfu,Li Yulin. Huang Wenkui.The Synthesis of Ethyl Cephalotaxinyl Oxalate and Its Application in the Synthesis of Cephalotaxus Ester Alkaloids[J].Chemical Research In Chinese Universities,1988,9(9):912. |
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| Authors: | Liu Xingping Wang Yongkeng Li Shaobai Pan Xinfu Li Yulin Huang Wenkui |
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| Institution: | Institute of Organic Chemistry, Lanzhou University, Lanzhou |
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| Abstract: | In this wrok, ethyl cephalotaxinyl oxalate was prepared by ester exchange and the synthesis of the key intermediate, α-keto-acetyl-cephalotaxine, was achieved by treating this oxalate with a Grignard reagent. This constitutes an efficient modification of previously reported mathods for the synthesis of cephalotaxus este ralkaloids. |
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| Keywords: | Ethyl cephalotaxmyl oxalate α-Keto-acetyl-cephaltaxme |
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