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Two Chiral Building Blocks for the Stereocontrolled Synthesis of Anti-and Syn-1,3-Diols

作者姓名：	Yong WU1* Mei GUAN2 Zheng XU1 Li Cheng1 Xiao Chun WU1 1School of Pharmacy Sichuan University Chengdu 610041 2The First Hospital Sichuan University Chengdu 610041

作者单位：	Yong WU1*，Mei GUAN2，Zheng XU1，Li Cheng1，Xiao Chun WU1 1School of Pharmacy，Sichuan University，Chengdu 610041 2The First Hospital，Sichuan University，Chengdu 610041

摘要：	During the last decade, chiral building blocks for 1, 3-diols of various configurations have been synthesized and applied widely in the total synthesis of natural polyene macrolide antibiotics1 and 1(, 25-dihydroxyvitamin D3 analogues2,3. The synthesis of the building block has attracted much interest in recent years. Herein, we report the synthesis of two chiral building blocks 1 and 2 in 8 steps and 7 steps respectively, starting from the readily available and inexpensive D (+)-xylose 3 as o…
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