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Two Chiral Building Blocks for the Stereocontrolled Synthesis of Anti-and Syn-1,3-Diols
作者姓名:Yong WU1*  Mei GUAN2  Zheng XU1  Li Cheng1  Xiao Chun WU1 1School of Pharmacy  Sichuan University  Chengdu 610041 2The First Hospital  Sichuan University  Chengdu 610041
作者单位:Yong WU1*,Mei GUAN2,Zheng XU1,Li Cheng1,Xiao Chun WU1 1School of Pharmacy,Sichuan University,Chengdu 610041 2The First Hospital,Sichuan University,Chengdu 610041
摘    要:During the last decade, chiral building blocks for 1, 3-diols of various configurations have been synthesized and applied widely in the total synthesis of natural polyene macrolide antibiotics1 and 1(, 25-dihydroxyvitamin D3 analogues2,3. The synthesis of the building block has attracted much interest in recent years. Herein, we report the synthesis of two chiral building blocks 1 and 2 in 8 steps and 7 steps respectively, starting from the readily available and inexpensive D (+)-xylose 3 as o…

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