| 注射用生物可降解胰岛素纳米微球的制备 |
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| 引用本文： | 皮洪琼,吴俊丽,等.注射用生物可降解胰岛素纳米微球的制备[J].应用化学,2001,18(5):365-0. |
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| 作者姓名： | 皮洪琼 吴俊丽 |
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| 作者单位： | 南开大学高分子所!吸附与分离功能高分子材料国家重点实验室天津300071(皮洪琼，吴俊丽，袁直)，南开大学高分子所!吸附与分离功能高分子材料国家重点实验室天(何炳林) |
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| 基金项目： | 国家教委博士点基金! (980 0 5 5 0 4)，南开大学吸附分离功能高分子材料国家重点实验室资助课题 |
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| 摘 要： | 共聚物;药剂释放体系;注射用生物可降解胰岛素纳米微球的制备
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| 关 键 词： | 共聚物 药剂释放体系 注射用生物可降解胰岛素纳米微球的制备 |
| 收稿时间： | 2009-06-29 |
| 修稿时间： | 2009-06-29 |
Preparation of Insulin Encapsulated Biodegradable PLA-PEG Copolymer Nanospheres |
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| PI Hong-Qiong ,WU Jun-Li,YUAN Zhi,HE Bing-Lin.Preparation of Insulin Encapsulated Biodegradable PLA-PEG Copolymer Nanospheres[J].Chinese Journal of Applied Chemistry,2001,18(5):365-0. |
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| Authors: | PI Hong-Qiong WU Jun-Li YUAN Zhi HE Bing-Lin |
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| Institution: | PI Hong-Qiong *,WU Jun-Li,YUAN Zhi,HE Bing-Lin |
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| Abstract: | Nanospheres with entrapped insulin were prepared by a solvent extraction method with a series of copolymers of DL -lactide(PLA) and polyethylene glycol(PEG)(INS/PELA) where the PEG is in different molecular weight and content. The nanospheres as TEM shows have a smooth and spherical surface sized between 100~200 nm. The amount of insulin in nanospheres and the entrapment ratio achieved 17 5% and 87 6%, respectively. In vitro studies indicated that release of insulin from nanospheres could last over 10 days. |
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| Keywords: | poly( DL -lactide- co -polyethylene glycol) biodegradable nanosphere insulin drug dilivery system |
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