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Cellular uptake of a fluorescent vanadyl sulfonylcalix[4]arene
Authors:Redshaw Carl  Elsegood Mark R J  Wright Joseph A  Baillie-Johnson Hugo  Yamato Takehiko  De Giovanni Stephen  Mueller Anja
Institution:Energy Materials Laboratory, School of Chemistry, The University of East Anglia, Norwich, NR4 7TJ, UK.
Abstract:Vanadyl bearing calix4]arene ligands have undergone evaluation against several cell lines, and show varying degrees of toxicity. For vanadyl complexed to a sulfonylcalix4]arene, monitoring of the strong blue fluorescence revealed slow uptake kinetics. The complex is exclusively found in the cytoplasm of the cells and uptake is not due to active endocytotic mechanisms.
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