Cellular uptake of a fluorescent vanadyl sulfonylcalix[4]arene |
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Authors: | Redshaw Carl Elsegood Mark R J Wright Joseph A Baillie-Johnson Hugo Yamato Takehiko De Giovanni Stephen Mueller Anja |
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Institution: | Energy Materials Laboratory, School of Chemistry, The University of East Anglia, Norwich, NR4 7TJ, UK. |
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Abstract: | Vanadyl bearing calix4]arene ligands have undergone evaluation against several cell lines, and show varying degrees of toxicity. For vanadyl complexed to a sulfonylcalix4]arene, monitoring of the strong blue fluorescence revealed slow uptake kinetics. The complex is exclusively found in the cytoplasm of the cells and uptake is not due to active endocytotic mechanisms. |
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