Direct preparation of thiazoles, imidazoles, imidazopyridines and thiazolidines from alkenes |
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| Authors: | Donohoe Timothy J Kabeshov Mikhail A Rathi Akshat H Smith Ian E D |
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| Affiliation: | Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, UK OX1 3TA. timothy.donohoe@chem.ox.ac.uk |
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| Abstract: | A range of heterocycles, namely thiazoles, imidazoles, imidazopyridines, thiazolidines and dimethoxyindoles, have been synthesised directly from alkenes via a two-step ketoidoination/cyclisation protocol. The alkene starting materials are themselves readily accessible using many different and well-established approaches, and allow access to a variety of heterocycles with excellent yields and regioselectivity. |
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