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Synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using [Et2NSF2]BF4 as a practical cyclodehydration agent
Authors:Pouliot Marie-France  Angers Laetitia  Hamel Jean-Denys  Paquin Jean-François
Institution:Department of Chemistry, Université Laval, Québec, Canada.
Abstract:The preparation of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using XtalFluor-E (Et(2)NSF(2)]BF(4)) as cyclodehydration reagent is described. Various functionalized 1,3,4-oxadiazoles were synthesized and it was found that the use of acetic acid as an additive generally improved the yields.
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