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Copper-free click--a promising tool for pre-targeted PET imaging |
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| Authors: | Evans Helen L Slade Rozanna L Carroll Laurence Smith Graham Nguyen Quang-De Iddon Lisa Kamaly Nazila Stöckmann Henning Leeper Finian J Aboagye Eric O Spivey Alan C |
| Affiliation: | Comprehensive Cancer Imaging Centre, Department of Surgery & Cancer, Hammersmith Campus, Imperial College, London, United Kingdom. |
| Abstract: | The copper-free click (CFC) reaction has been evaluated for its potential application to in vivo pre-targeting for PET imaging. A promising biodistribution profile is demonstrated when employing [(18)F]2-fluoroethylazide ([(18)F]1) and optimisation of the CFC reaction with a series of cyclooctynes shows that reactions proceed efficiently with tantalizing opportunities for application-specific tuning. |
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