Synthesis and characterization of complexes of Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) with macrocycle 3,4,11,12-tetraoxo-1,2,5,6,9,10,13,14-octaaza-cyclohexadeca-6,8,14,16-tetraene and their biological screening |
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Authors: | Email author" target="_blank">D?P?SinghEmail author Ramesh?Kumar Vandna?Malik Parikshit?Tyagi |
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Institution: | (1) Department of Chemistry, National Institute of Technology, Kurukshetra, 136 119, India;(2) Serum Institute of India Ltd, 212/2, Hadapsar, Pune, 411 028, India |
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Abstract: | A new series of complexes is synthesized by template condensation of glyoxal and oxalyldihydrazide in methanolic medium in
the presence of divalent cobalt, nickel, copper, zinc and cadmium salts forming complexes of the type: M(C8H8N8O4)X2] where M = Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and X = Cl−1, Br−1, NO
3
−1
, OAc−1. The complexes have been characterized with the help of elemental analyses, conductance measurements, magnetic susceptibility
measurements, electronic, n.m.r., infrared and far infrared spectral studies. On the basis of these studies, a six coordinate
octahedral geometry for these complexes has been proposed. The biological activities of the metal complexes have been tested
in vitro against a number of pathogenic bacteria to assess their inhibiting potential. Most of the compounds have been found to exhibit
remarkable antibacterial activities. |
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Keywords: | |
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