| Crystal Structure of Loliolide (5, 6,7a-Tetrahydro-6-hydroxy-4, 4, 7a-trimethyl-2 (4H)-benzofuranones) |
| |
| 引用本文： | CHEN Jing-Yu, CHEN Jian-Min, XIAO Pei-Gen(Institute of Medicinal Plant Development,the Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100094)WU Nan, LU Yang(Institute of Materia Medica,the Chinese Academy of Medical Sciences,P. Crystal Structure of Loliolide (5, 6,7a-Tetrahydro-6-hydroxy-4, 4, 7a-trimethyl-2 (4H)-benzofuranones)[J]. 结构化学, 1997, 0(5) |
| |
| 作者姓名： | CHEN Jing-Yu CHEN Jian-Min XIAO Pei-Gen(Institute of Medicinal Plant Development the Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100094)WU Nan LU Yang(Institute of Materia Medica the Chinese Academy of Medical Sciences P |
| |
| 作者单位： | CHEN Jing-Yu; CHEN Jian-Min; XIAO Pei-Gen(Institute of Medicinal Plant Development，the Chinese Academy of Medical Sciences，Peking Union Medical College，Beijing 100094 |
| |
| 摘 要： | 1INTRODUCTIONThetitlecompound,C,,H,,O,(mp:146～148'C),forthefirsttime,wasiso-latedfromClinopodiumpolycephalum(Vant-)byC.Y.WuetHsuancalled"DuanXueliu"inChinesethatisusedinfolkmedicineforthetreatmentofhaemorrhagiadisease[1i.Itsstructurehasalreadybeendeterminedt2ibymeansofUV,lR,NMRandchemicalsynthesis.Sinceloliolideappearedtohaveantitumoractivity"'andim-munosuppressiveactivity'#'inrecentyears,weaffirmedthestructurebyX-raydiffractionanalysis.2EXPERIMENTALApaleyellowtransparentcry…
|
Crystal Structure of Loliolide (5, 6,7a-Tetrahydro-6-hydroxy-4, 4, 7a-trimethyl-2 (4H)-benzofuranones) |
| |
| CHEN Jing-Yu, CHEN Jian-Min, XIAO Pei-Gen. Crystal Structure of Loliolide (5, 6,7a-Tetrahydro-6-hydroxy-4, 4, 7a-trimethyl-2 (4H)-benzofuranones)[J]. Chinese Journal of Structural Chemistry, 1997, 0(5) |
| |
| Authors: | CHEN Jing-Yu CHEN Jian-Min XIAO Pei-Gen |
| |
| Abstract: | The structure of the title compound, which was isolated fromClinopodium polycephalum (Vant.) by C. Y. Wu et Hsuan, has been determined byX-ray diffraction analysis. C11H16O3, Mr= 196. The crystal belongs to the monoclinicspace group P21 with a= 6. 072 (3), b=11. 682 (5), c= 7. 865 (4) A, β= 109. 61(4)°, V=525. 5(4) , Z= 2, F(000) =212, Dc= 1.234 g/cm3, μ=0.08 mm-1.The structure was solved by direct methods and refined to R=0. 048 for 616 observedreflections. The molecule is composed of a six-membered ring and a five-membered lactone ring with a methyl and a hydroxy group at the two asymmetrical carbons locatedon the same side of the nucleus. |
| |
| Keywords: | clinopodium polycephalum lolioide crystal structure antitumor activity |
| 本文献已被 CNKI 等数据库收录！ |
|
