Radical cyclization approach to spirocyclohexadienones |
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| Authors: | de Turiso Felix González-López Curran Dennis P |
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| Affiliation: | Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. |
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| Abstract: | Cyclization of an aryl radical at the ipso position of a p-O-aryl-substituted acetamide or benzamide generates oxindoles or quinolones bearing spirocyclohexadienone rings. This versatile reaction is applied to formal syntheses of the vasopressin inhibitor SR121463A and aza-galanthamine. |
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