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| N-甲氧基-N-[2-(1,6-2H-1-取代-6-羰基-哒嗪-3-氧甲基)苯基]氨基甲酸甲酯的合成及生物活性研究 | |
| 引用本文： | 刘卫东,李志伟,李仲英,王晓光,高必达.N-甲氧基-N-[2-(1,6-2H-1-取代-6-羰基-哒嗪-3-氧甲基)苯基]氨基甲酸甲酯的合成及生物活性研究[J].有机化学,2005,25(4):445-448. |
| 作者姓名： | 刘卫东 李志伟 李仲英 王晓光 高必达 |
| 作者单位： | 1. 湖南化工研究院国家南方农药创制中心湖南基地,长沙,410007;湖南农业大学生物安全科技学院,长沙,410128 2. 湖南大学化学化工学院,长沙,410082 3. 湖南化工研究院国家南方农药创制中心湖南基地,长沙,410007 4. 湖南农业大学生物安全科技学院,长沙,410128 |
| 基金项目： | 国家科技攻关项目，湖南省杰出青年科学基金 |
| 摘 要： | 为了寻找高效、低毒的农药, 设计合成了一系列新的N-甲氧基-N-2-(1,6-2H-1-取代-6-羰基-哒嗪-3-氧甲基)苯基]氨基甲酸甲酯化合物3a～3k, 其结构经IR, 1H NMR, LC/MS和元素分析确认. 生物活性测定表明, 部分化合物在50 mg/L下对小麦赤霉病菌(Gibberella zeae)、稻瘟病菌(Pyricularia oryzae)和黄瓜灰霉病菌(Botrytis cinerea)有较好的抑菌活性. |
| 关 键 词： | 哒嗪酮 N-甲氧基氨基甲酸酯 合成 杀菌活性 |
| 收稿时间： | 2004-7-12 |
| 修稿时间： | 2004年7月12日 |
Synthesis and Biological Activity of Methyl N-Methoxy-N-[2-(1,6-dihy- |
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| LIU Wei-Dong,LI Zhi-Wei,LI Zhong-Ying,WANG Xiao-Guang,GAO Bi-Da.Synthesis and Biological Activity of Methyl N-Methoxy-N-[2-(1,6-dihy-[J].Chinese Journal of Organic Chemistry,2005,25(4):445-448. | |
| Authors: | LIU Wei-Dong LI Zhi-Wei LI Zhong-Ying WANG Xiao-Guang GAO Bi-Da |
| Institution: | ( Hunan Research Institute of Chemical Industry, National Pesticide Research and Development Southern Center Hunan Branch, Changsha 410007)(College of Chem-istry and Chemical Engineering, Hunan University, Changsha 410082)(College of Bio-Safety Science and Technology, Hunan Agricultural University, Changsha 410128) |
| Abstract: | In an attempt to find novel compounds with high activity and low toxicity, a series of novel methyl N-methoxy-N-2-(1,6-dihydro-1-substituent-6-oxo-pyridazin-3-yloxymethyl)phenyl]carbamate derivatives 3a～3k were designed and synthesized by bioisoster principle. Their structures were confirmed by 1H NMR, IR, LC/MS spectra and elemental analysis. The preliminary biological activity tests show that some compounds possess fungicidal activities against Pyricularia oryzae, Botrytis cinerea and Erysiphe graminis. |
| Keywords: | pyridazinone N-methoxylcarbamate synthesis fungicidal activity |
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