Expedient parallel synthesis of 2-amino-4-heteroarylpyrimidines |
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| Authors: | Bursavich Matthew G Lombardi Sabrina Gilbert Adam M |
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| Institution: | Exploratory Medicinal Chemistry, Chemical and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA. bursavm@wyeth.com |
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| Abstract: | reaction: see text] An expedient synthesis of diverse 2-amino-4-heteroarylpyrimidines via a 2-chloropyrimidine intermediate is described. A series of potentially biologically active analogues have been synthesized in two parallel steps to afford focused arrays. |
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