Thermochemistry of aqueous solutions of alkylated nucleic acid bases. IX. Enthalpies of hydration of 9-methyl-8-alkyladenines and 6,9-dimethyl-8-alkyladenines |
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Authors: | W Zielenkiewicz A Zielenkiewicz K L Wierzchowski |
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Institution: | (1) Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland;(2) Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Rakowiecka 36, 02-532 Warsaw, Poland |
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Abstract: | Enthalpies of solution in water, H
sol
o
, and enthalpies of sublimation, H
sub
o
, were determined experimentally for a number of crystalline derivatives of adenine: 6,8,9-trimethyladenine; 6,9-dimethyl-8-ethyladenine; 6,9-dimethyl-8-propyladenine; 6,9-dimethyl-8-butyladenine; 8,9-dimethyl-adenine and 9-methyl-8-ethyladenine. Standard enthalpies of hydration, H
hydr
o
, derived from these data were calculated. The latter were discussed together with the values for variously alkylated adenines, determined previously. The data obtained show that the dependence of enthalpy of hydration on the number of methylene groups added upon substitution with 8-n-alkyl groups of 9-methyladenine and 6,9-dimethyladenine is nonlinear. |
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Keywords: | Alkylated adenines enthalpy of solution enthalpy of sublimation enthalpy of hydration |
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