Radical deoxygenation of hydroxyl groups via phosphites |
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| Authors: | Zhang Liming Koreeda Masato |
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| Affiliation: | Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA. |
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| Abstract: | A highly efficient, two-step sequence method for the deoxygenation of hydroxyl groups has been developed. The method involves the preparation of the 2-(2-iodophenyl)ethyl methyl phosphite derivative of an alcohol using methyl dichlorophosphite and 2-(2-iodophenyl)ethanol. Treatment of the phosphite intermediate with (n-Bu)3SnH/AIBN in refluxing benzene cleanly produces the deoxygenation product of the original alcohol. |
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