4-Hydroxy-2-quinolones 145. p-Toluenesulfonylhydrazide as a tosylating agent |
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| Authors: | I. V. Ukrainets A. A. Tkach V. V. Kravtsova S. V. Shishkina |
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| Affiliation: | (1) National Pharmaceutial University, Kharkiv, 61002, Ukraine;(2) STC Institute for Single Crystal, Ukraine National Academy of Sciences, Kharkiv, 61001, Ukraine |
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| Abstract: | The reaction of ethyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate with p-toluene-sulfonylhydrazide in anhydrous solvents in the presence of triethylamine results in the tosylation of position 4 of the quinolone. Features of the steric structure of the tosyl-substituted compound are discussed. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 847–852, June, 2008. |
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| Keywords: | 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylate p-toluenesulfonylhydrazide X-ray structural analysis tosylation |
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