The inclusion of the drug diflunisal by alpha- and beta-cyclodextrins. A nuclear magnetic resonance and ultraviolet spectroscopic study期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

The inclusion of the drug diflunisal by alpha- and beta-cyclodextrins. A nuclear magnetic resonance and ultraviolet spectroscopic study

Authors:	Stephen F. Lincoln John H. Coates Bruce G. Doddridge Andrea M. Hounslow

Affiliation:	(1) Department of Physical and Inorganic Chemistry, University of Adelaide, 5001 Adelaide, South Australia

Abstract:	¹⁹F nmr and ultraviolet spectroscopic studies show that the inclusion of the anion of the drug diflunisal (DF) by alpha- and beta- cyclodextrins (CD and CD) in water produces the complexes: DF.CD, DF.CD and DF.(CD)₂ characterized by stability constants of 17, 1.81×10⁵ and 3.07×10³ dm³mol^–1 respectively.

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