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Controlled release of dexamethasone from porous PLGA scaffolds under cyclic loading |
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| Authors: | TANG GongWen YANG YanFang SUN AiPing SONG TianTian ZHAO YunHui YUAN XuBo YUAN XiaoYan FAN YuBo & WANG Min Tianjin Key Laboratory of Composite Functional Materials School of Materials Science Engineering Tianjin University Tianjin China School of Biological Science Medical Engineering Beihang University Beijing |
| Affiliation: | TANG GongWen1,YANG YanFang1,SUN AiPing1,SONG TianTian1,ZHAO YunHui1,YUAN XuBo1,YUAN XiaoYan1,FAN YuBo2 & WANG Min3 1 Tianjin Key Laboratory of Composite , Functional Materials,School of Materials Science , Engineering,Tianjin University,Tianjin 300072,China,2 School of Biological Science , Medical Engineering,Beihang University,Beijing 100083,3 Department of Mechanical Engineering,The University of Hong Kong,Hong Kong |
| Abstract: | Poly(L-lactide)-b-poly(ethylene glycol)(PLLA-PEG) microspheres containing dexamethasone(Dex) have been fabricated using a spray-drying technique.Porous poly(lactic-co-glycolic acid)(PLGA) scaffolds were prepared using a method combining thermally induced phase separation and porogen leaching.A post-seeding technique was used to immobilize Dex-containing PLLA-PEG microspheres on porous PLGA scaffolds,and drug-containing microspheres-scaffolds(MS-S) were obtained.Simple Dex-containing scaffolds(D-S) were also... |
| Keywords: | microsphere dexamethasone scaffold PLGA cyclic loading |
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