Delineating noncovalent interactions between the azinomycins and double-stranded DNA: importance of the naphthalene substitution pattern on interstrand cross-linking efficiency |
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| Authors: | Landreau Cyrille A S LePla Rachel C Shipman Michael Slawin Alexandra M Z Hartley John A |
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| Institution: | Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, U.K., School of Chemistry, University of St. Andrews, Purdie Building, St. Andrews, Fife KY16 9ST, UK. |
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| Abstract: | reaction: see text] Using a series of synthetic azinomycin analogues, it is shown that the efficiency of in vitro DNA interstrand cross-linking is markedly reduced when either the C-5' methyl group or both the C-5' methyl and C-3' methoxy groups are deleted from the naphthalene ring. |
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