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Synthesis,characterization and antimicrobial activity of novel sulphapiperazine containing arylazopyrazoles
Authors:Purvesh J Shah  Hasmukh S Patel  Bhupendra P Patel
Institution:Department of Chemistry, Sardar Patel University, Vallabh Vidhyanagar 388 120, India
Abstract:Mannich reaction of benzotriazole (1), ethyl-4-amino benzoate (2) and formaldehyde in ethanol afforded 4-(1H)-benzotriazoyl methyl amino benzoate (3), which on treatment with hydrazine hydrate results in the 4-(1H)-benzotriazoyl methyl amino benzoyl hydrazide (4). This compound on condensation with pre-prepared various ethyl-2-substituted phenyl hydrazono-3-oxobutyrates (6a–h), furnished 1-(4-((1H-benzod]1,2,3]triazol-1-yl) methyl amino) benzoyl)-3-methyl-4-(2-(4-(4-alkylpiperazin-1-ylsulfonyl) phenyl) hydrazono)-1H-pyrazol-5(4H)-ones (7a–h). All these compounds (7a–h) were characterized by spectral studies. The compounds showed significant antimicrobial activity against various bacteria and fungi.
Keywords:Pyrazole  Benzotriazole  Spectral studies  Antibacterial activity  Antifungal activity
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