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Antifungal activities of amino acid ester functional pyrazolyl compounds against Fusarium oxysporum f.sp. albedinis and Saccharomyces cerevisiae yeast |
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| Authors: | Nouria Boussalah Rachid Touzani Faiza Souna Iman Himri Mohammed Bouakka Abdelkader Hakkou Said Ghalem Sghir El Kadiri |
| Institution: | 1. Laboratoire des Substances Naturelles et Bioactives, Département de Chimie, Faculté des Sciences, Université Abou Bekr Belkaid-Tlemcen, BP: 119, Tlemcen 13000, Algeria;3. Faculté Pluridisciplinaire de Nador, BP:300, Selouane 62700, Nador, Morocco |
| Abstract: | Series of functional multidendate ligands based on pyrazole and amino acid derivatives were prepared in good and excellent yields (75–5%) by condensation of one equivalent of amino acid ester hydrochloride substrates with two equivalents of (3,5-dimethyl-1H–pyrazol-1-yl)methanol. These tridentate functionalized compounds and their starting materials were screened for their antifungal activities against Fusarium oxysporum f.sp. albedinis and the yeast of Saccharomyces cerevisiae. Considerable activities were recorded with respect to the two studied microorganisms. |
| Keywords: | Multidentate ligands Pyrazole Amino acid ester hydrochlorides Antifungal activities |
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