| PRLs Promote Spreading, Adhesion, and Proliferation of Human SW480 and SW620 Cells |
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| 作者姓名： | LI Zhao-fa XU Xue-song SHEN Xing-gui LI Qing-shan ZHAO Zhi-zhuang FU Xue-qi LI Yu-lin LI Yi-lei |
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| 作者单位： | [1]Edmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin University, Changchun 130021, P. R. China [2]China-Japan Union Hospital, Jilin University, Changchun 130031, P. R. China [3]The Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130023, P. R. China |
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| 基金项目： | Supported by 0pen Foundation of State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University. |
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| 摘 要： | IntroductionMetastasis is the leading cause of the death ofcancer patients.It represents a complex and multi-stepprocess including the detachment of tumor cells from aprimary cancer,the invasion into the surrounding tis-sue,the entry into the circulatory system,the reinva-sion,and the proliferation at a distant secondarysite1,2].A wide variety of stimuli are known to be as-sociated with the metastasis of tumor cells,which in-clude cytokines,hormones,growth factors,and extra-cellular matrix pr…
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| 关 键 词： | 分芽繁殖 PRL SW480细胞 直肠癌 癌细胞转移 突变异种 |
| 文章编号： | 1005-9040（2006）-01-068-05 |
| 收稿时间： | 2005-03-02 |
PRLs Promote Spreading, Adhesion, and Proliferation of Human SW480 and SW620 Cells |
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| LI Zhao-fa XU Xue-song SHEN Xing-gui LI Qing-shan ZHAO Zhi-zhuang FU Xue-qi LI Yu-lin LI Yi-lei.PRLs Promote Spreading, Adhesion, and Proliferation of Human SW480 and SW620 Cells[J].Chemical Research in Chinese University,2006,22(1):68-72. |
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| Authors: | Zhao-fa LI Xue-song XU Xing-gui SHEN Qing-shan LI Zhi-zhuang ZHAO Xue-qi FU Yu-lin LI Yi-lei LI |
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| Institution: | aEdmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin University, Changchun 130021, P. R. China;bChina-Japan Union Hospital, Jilin University, Changchun 130031, P. R. China;cThe Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130023, P. R. China |
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| Abstract: | Recent studies suggest that PRL-3 is involved in the metastasis of colorectal cancer, but the mechanism concerning that has not been well defined. This article expresses PRL-1, PRL-2, and PRL-3 and the catalytically inactive mutant forms of those enzymes in SW620 and SW480 cells, two human cell lines derived from non-metastatic cancer and metastatic colorectal cancer, respectively. While the expression of the native forms of PRLs promotes the spreading, adhesion, and proliferation of these cells, the expression of their mutant forms inhibits the earlier-mentioned processes. These data thus provide a cellular mechanism for the role of PRL-3 in tumor metastasis and suggest that all the three PRLs have similar functions. |
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| Keywords: | PRL Metastasis Proliferation Expression SW480 cell SW620 cell |
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