Reactivity of mixed organozinc and mixed organocopper reagents: 6. Nickel-catalyzed coupling of methylarylzincs with primary alkyl halides; an atom-economic aryl-alkyl coupling |
| |
Authors: | Ö zgen Ö mü r PekelEnder Erdik |
| |
Affiliation: | Ankara University, Science Faculty, Be?evler, Ankara 06100, Turkey |
| |
Abstract: | A nickel-catalyzed process for the cross-coupling of mixed arylzincs and primary alkyl halides has been developed. The reaction of a methylarylzinc with a primary alkyl halide in THF in the presence of NiCl2/PPh3 takes place with selective aryl transfer at room temperature in moderate yields. This protocol provides an atom-economic alternative to aryl-primary alkyl coupling using diarylzincs. |
| |
Keywords: | Alkylarylzincs Mixed diorganozincs Alkylation Triphenylphosphine |
本文献已被 ScienceDirect 等数据库收录! |