| 二苯乙烯衍生物的合成与抗癌活性的初步研究 |
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| 引用本文： | 刘小莉,张喜全,郭键,徐宏江,李宝林.二苯乙烯衍生物的合成与抗癌活性的初步研究[J].化学通报,2009,72(2). |
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| 作者姓名： | 刘小莉 张喜全 郭键 徐宏江 李宝林 |
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| 作者单位： | 刘小莉,郭键,李宝林,Liu Xiaoli,Guo Jian,Li Baolin(教育部药用资源与天然药物化学重点实验室,陕西师范大学化学与材料科学学院,西安,710062);张喜全,徐宏江,Zhang Xiquan,Xu Hongjiang(江苏正大天晴药业股份有限公司,南京,210038)
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| 基金项目： | 教育部重点科学技术研究项目 |
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| 摘 要： | 以对硝基甲苯和3,4,5-三甲氧基苯甲醛或3,4-二甲氧基苯甲醛为起始原料,经过缩合、还原和酰化反应,合成了(E)-3,4,5-三甲氧基-4'-乙酰氨基二苯乙烯等4种二苯乙烯衍生物.4种化合物对HepG2和BGC-823两种细胞模型的体外抗癌活性测试结果表明,这些化合物具有良好的抗肿瘤活性且对正常细胞毒性较小.
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| 关 键 词： | 白藜芦醇类似物 二苯乙烯衍生物 抗肿瘤活性 |
Synthesis and Primary Study on Anti-tumor Activity of Stilbene Derivatives |
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| Liu Xiaoli,Zhang Xiquan,Guo Jian,Xu Hongjiang,Li Baolin.Synthesis and Primary Study on Anti-tumor Activity of Stilbene Derivatives[J].Chemistry,2009,72(2). |
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| Authors: | Liu Xiaoli Zhang Xiquan Guo Jian Xu Hongjiang Li Baolin |
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| Institution: | ~1Key Laboratory of Medicinal Resource & Natural Pharmaceutical Chemistry of Ministry of Education;School of Chemistry and Materials Science;Shaanxi Normal University;Xi'an 710062;~2Jiangsu Chia Tai Tianqing Pharmaceutical Co.;Ltd. Nanjing 210038 |
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| Abstract: | Four stilbene derivatives such as (E)-3, 4, 5-trimethoxy-4'-acetylaminostilbene etc. were synthesized from p-nitrotoluene and 3, 4, 5-trimethoxybenzaldehyde or 3, 4-dimethoxybenzaldehyde via multiple steps including condensation, catalytic reduction and acylation. The anti-tumor activities of these compounds were tested preliminarily on Hep G2 and BGC-823 cells. The results indicated that these compounds showed better anti-tumor effects and less toxicity to normal cell. |
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| Keywords: | Resveratrol analogues Stilbene derivatives Anti-tumor activities |
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