Asymmetric multicomponent reactions: diastereoselective synthesis of substituted pyrrolidines and prolines |
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| Authors: | Ghosh Arun K Kulkarni Sarang Xu Chun-Xiao Fanwick Phillip E |
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| Affiliation: | Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA. akghosh@purdue.edu |
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| Abstract: | A novel diastereoselective synthesis of substituted pyrrolidines has been developed. Asymmetric multicomponent reactions of optically active phenyldihydrofuran, N-tosyl imino ester, and silane reagents in a one-pot operation afforded highly substituted pyrrolidine derivatives diastereoselectively. The reaction is quite efficient and constructed up to three stereogenic centers in a single operation. |
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