LC-QqLIT MS analysis of nine sulfonamides and one of their acetylated metabolites in the Llobregat River basin. Quantitative determination and qualitative evaluation by IDA experiments |
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Authors: | M Jesús García-Galán Marta Villagrasa M Silvia Díaz-Cruz Damià Barceló |
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Institution: | 1. Department Environmental Chemistry, Institute of Environmental Diagnostic and Water Studies (IDAEA), Spanish Council of Scientific Research (CSIC), Jordi Girona 18-26, 08034, Barcelona, Spain 2. Catalan Institute for Water Research (ICRA), Emili Grahit 101, Edifici H2O, Parc Científic i Tecnològic de la Universitat de Girona, 17003, Girona, Spain
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Abstract: | Robust instrumental analytical chemistry and the subsequent development of improved analytical methodologies and extraction
procedures have enabled the detection at environmental levels of new emerging contaminants, for example pharmaceuticals. The
objective of this study was to explore the potential of liquid chromatography–tandem quadrupole-linear ion trap (LC–QqLIT
MS) for quantitative determination of nine sulfonamides (SAs) and one acetylated metabolite in surface water from the Llobregat
River and one of its main tributaries, the Anoia River, in Catalonia (Spain). A total of 21 samples were taken in three sampling
campaigns. Recoveries ranging from 26% to 123% were calculated for the SAs studied, and method limits of detection (MLODs)
achieved were in the range 0.05–0.2 ng L−1. Through the different campaigns, concentrations ranged from 0.74 ng L−1 (sulfamethizole) to 2,482 ng L−1 (sulfamethazine) in the Llobregat River, and from 0.27 ng L−1 (sulfamethizole) to 168 ng L−1 (sulfamethoxazole) in the Anoia River. Sulfamethoxazole and sulfapyridine were the two SAs most frequently detected (80%
and 71% respectively). N
4-acetylsulfamethazine was detected in both rivers, but with different frequencies (4% of the samples from the Anoia River
and 43% of those from the Llobregat River). Information-dependent acquisition (IDA) experiments were also developed in order
to obtain enhanced product-ion spectra in surface water samples. |
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