Analysis of the carcinogen 4,4′-methylenedianiline (MDA) in gamma-ray and in autoclave-sterilized polyurethane |
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| Authors: | Hideharu Shintani and Akitada Nakamura |
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| Affiliation: | (1) Department of Medical Devices, National Institute of Hygienic Sciences, 1-18-1, Kamiyoga, Setagaya, 158 Tokyo, Japan |
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| Abstract: | Summary A carcinogen, 4,4 -methylenedianiline (MDA, p,p-diaminodiphenylmethane), was determined in gammaray- and in autoclave-sterilized thermoplastic polyurethane (PU). The determination of MDA in aqueous extracts of PU has been reported, however recovery of MDA and its determination using a complete dissolution of PU by organic solvents have not. In addition, we report the MDA determination in methanol extract of PU. No MDA was detected in gamma-ray sterilized thermoplastic PU, but in autoclavesterilized thermoplastic PU, MDA was detected (possibly formed by hydrolysis). The amount of MDA formed was inversely related to the molecular weight of PU by a second order equation. No change in the weight average molecular weight was observed as a result of autoclave sterilization. Essentially the same amounts of MDA were extracted from PU with serum as with methanol.
Analyse des Carcinogens 4,4 -Methylendianilin (MDA) in  -Strahlen- und Autoklav-sterilisiertem Polyurethan |
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