New Kendomycin Derivative Isolated from Streptomyces sp. Cl 58-27 |
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| Authors: | Constanze Paulus Oleksandr Gromyko Andriy Luzhetskyy |
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| Institution: | 1.Department of Pharmaceutical Biotechnology, Saarland University, 66123 Saarbrücken, Germany;2.Department of Genetics and Biotechnology, Ivan Franko University of Lviv, 79005 Lviv, Ukraine;3.AMEG Department, Helmholtz Institute for Pharmaceutical Research Saarland, 66123 Saarbrücken, Germany |
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| Abstract: | In the course of screening new streptomycete strains, the strain Streptomyces sp. Cl 58-27 caught our attention due to its interesting secondary metabolite production profile. Here, we report the isolation and characterization of an ansamycin natural product that belongs structurally to the already known kendomycins. The structure of the new kendomycin E was elucidated using NMR spectroscopy, and the corresponding biosynthetic gene cluster was identified by sequencing the genome of Streptomyces sp. Cl 58-27 and conducting a detailed analysis of secondary metabolism gene clusters using bioinformatic tools. |
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| Keywords: | polyketide synthases Streptomyces ansamycins |
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