A novel 18-norclerodane diterpenoid from the roots of Tinospora sagittata var. yunnanensis |
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| Authors: | Huang Xiang-Zhong Cheng Chun-Mei Dai Yun Fu Guang-Miao Guo Jun-Ming Yin Yan Liang Hui |
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| Affiliation: | Key Laboratory of Ethnic Medicine Resource Chemistry, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650031, China. fugmiao@yahoo.com.cn. |
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| Abstract: | A novel 18-nor-clerodane diterpenoid named sagitone (1) was isolated from the 95% ethanol extract of dry roots of Tinospora sagittata var. yunnanensis together with the five known diterpenoids columbin (2), palmatoside C (3), fibleucin (4), tinophylloloside (5) and epitinophylloloside (6). The structure of the new compound 1 was determined based on MS, IR, 1D and 2D NMR spectral data. The compounds 1-6 did not show significant cytotoxic activity against cancer cell lines K562 and HL-60. |
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