Water-driven ligations using cyclic amino squarates: a class of useful SN1-like reactions |
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| Authors: | Cui Dawei Prashar Deepali Sejwal Preeti Luk Yan-Yeung |
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| Affiliation: | Department of Chemistry, Syracuse University, Syracuse, NY 13244, USA. |
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| Abstract: | We report a class of water-soluble and -stable cyclic amino squarates that ligate with cysteine or lysine residues without side-products in an entirely aqueous environment. The ligations include addition-elimination reactions that are promoted by water in a way similar to S(N)1 reactions. The structural versatility of the reactants allows the potential recognition of selected amino acid residues on proteins. |
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