JIAN Fang-fang **,WANG Huan-xiang,XIAO Hai-lian and JIAO Kui New Materials & Function Coordination Chemistry Laboratory,Qingdao University of Science and Technology,Qingdao 266042,P. R. China
基金项目:
Supported by the Natural Science Foundation of Shandong Province(No.Y2 0 0 2 B0 6 )
摘 要:
IntroductionBenzimidazole is an interesting heterocyclicring because it is present in various natural occur-ring drugs such as omeprazole,astemizole andemedastine difumarate[1] .The efficacy of substitu-ted benzimidazoles in the treatment of parasitic in-fections is well known[2 _ 4] .Substituted benzimida-zole moieties are the established pharmacophores inparasitic chemotherapy. Bis( 2 - benzimidazoles) andsome substituted bis( 2 - benzimidazolyl) alkaneshave attracted much attention of some …