| Studies of the Total Synthesis of Epothilone B and D:A Facile Synthesis of C7-C14 and C15-C21 Fragments |
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| 引用本文： | He Sheng ZHANG Chuan Fu ZHONG 等. Studies of the Total Synthesis of Epothilone B and D:A Facile Synthesis of C7-C14 and C15-C21 Fragments[J]. 中国化学快报, 2003, 14(2): 115-117 |
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| 作者姓名： | He Sheng ZHANG Chuan Fu ZHONG 等 |
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| 作者单位： | DepartmentofChemistry,HubeiUniversity,Wuhan430062 |
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| 基金项目： | the National Natural Science Foundation of China (No.20214),Ministry of Education，Natural Science Foundation and Education Commission of Hubei Province |
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| 摘 要： | A mild and highly efficient synthesis of C7-C14 and C15-C21 fragments of epothilone B and D is described in which racemic C7-C14 fragment is prepared from nerol through four steps and C15-C21 fragment is obtained from 1,3-dichloroacctone.thioacetamide and propionaldehyde.
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| 关 键 词： | 碳环化合物 全合成 碳7片段 碳14片段 碳15片段 碳21片段 碳酸氢钠 碘化钠 |
Studies of the Total Synthesis of Epothilone B and D: A Facile Synthesis of C7-C14 and C15-C21 Fragments |
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| He Sheng ZHANG,Chuan Fu ZHONG,Xiao Ping BAO. Studies of the Total Synthesis of Epothilone B and D: A Facile Synthesis of C7-C14 and C15-C21 Fragments[J]. Chinese Chemical Letters, 2003, 14(2): 115-117 |
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| Authors: | He Sheng ZHANG Chuan Fu ZHONG Xiao Ping BAO |
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| Abstract: | A mild and highly efficient synthesis of C7-C14 and C15-C21 fragments of epothilone B and D is described in which racemic C7-C14 fragment is prepared from nerol through four steps, and C15-C21 fragment is obtained from 1, 3-dichloroacetone, thioacetamide and propionaldehyde. |
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| Keywords: | Epothilone B and D anticancer drugs nerol synthesis. |
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