| Diastereoselective Synthesis of Chiral Pyrrolidine and Piperidine Ring Systems |
| |
| 作者姓名： | 邵志会 彭芳芝 朱保昆 涂永强 张洪彬 |
| |
| 作者单位： | [1]StateKeyLaboratoryofAppliedOrganicChemistry,LanzhouUniversity,Lanzhou,Gansu730000,China [2]SchoolofPharmacy,YunnanUniversity,Kunming,Yunnan650091,China |
| |
| 基金项目： | Project supported by the National Natural Science Foundation of China (No. 20272049). |
| |
| 摘 要： | A diastereoselective method for the synthesis of chiral pyrrolidine and piperidine ring containing compounds was described. The protocol of bromination followed by aminocyclization furnishes an easily handled while highly efficient procedure for the intramolecular amidation of an isolated double bond. High diastereomeric excess was observed in this synthetic procedure.
|
| 关 键 词： | 立体选择性合成 吡咯 哌啶 氨基环化作用 手性化合物 |
Diastereoselective Synthesis of Chiral Pyrrolidine and Piperidine Ring Systems |
| |
| SHAO,Zhi-Huia,b PENG,Fang-Zhib ZHU,Bao-Kunb TU,Yong-Qianga ZHANG,Hong-Bin,b a State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou,Gansu ,China b School of Pharmacy,Yunnan University,Kunming,Yunnan ,China.Diastereoselective Synthesis of Chiral Pyrrolidine and Piperidine Ring Systems[J].Chinese Journal of Chemistry,2004,22(7):727-731. |
| |
| Authors: | SHAO Zhi-Huia b PENG Fang-Zhib ZHU Bao-Kunb TU Yong-Qianga ZHANG Hong-Bin b a State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou Gansu China b School of Pharmacy Yunnan University Kunming Yunnan China |
| |
| Institution: | SHAO,Zhi-Huia,b PENG,Fang-Zhib ZHU,Bao-Kunb TU,Yong-Qianga ZHANG,Hong-Bin*,b a State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou,Gansu 730000,China b School of Pharmacy,Yunnan University,Kunming,Yunnan 650091,China |
| |
| Abstract: | A diastereoselective method for the synthesis of chiral pyrrolidine and piperidine ring containing compounds was described. The protocol of bromination followed by aminocyclization furnishes an easily handled while highly efficient procedure for the intramolecular amidation of an isolated double bond. High diastereomeric excess was observed in this synthetic procedure. |
| |
| Keywords: | diastereoselective pyrrolidine piperidine aminocyclization |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
