| 离子液体-水介质中离子液体负载TEMPO催化选择氧化合成脂肪醇羟基芳香醛和酮 |
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| 引用本文： | 胡瑞君a 雷鸣a 卫禾耕b,王彦广a.离子液体-水介质中离子液体负载TEMPO催化选择氧化合成脂肪醇羟基芳香醛和酮[J].中国化学,2009,27(3):587-592. |
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| 作者姓名： | 胡瑞君a 雷鸣a 卫禾耕b 王彦广a |
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| 作者单位： | a浙江大学化学系, 浙江杭州 310027 ;b浙江海正药业股份有限公司, 浙江台州 318000 ; |
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| 摘 要： | 由于脂肪醇羟基和苄醇羟基具有相同的氧化反应活性，所以当分子内同时含有脂肪醇羟基和苄醇羟基时，很难选择氧化苄醇羟基合成含脂肪醇羟基的芳香醛或酮。本文报道了在离子液体-水介质中，NCS/NaBr/IL-TEMPO（离子液体负载TEMPO）催化氧化合成含有脂肪醇羟基的芳香醛、酮的方法，反应条件温和，选择性好，收率高，且离子液体和催化剂可以循环使用。
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| 关 键 词： | 选择氧化 TEMPO 同时含有脂肪醇羟基和苄醇羟基的二醇 含脂肪醇羟基的芳香醛或酮 离子液体 |
| 收稿时间： | 2008-7-10 |
| 修稿时间： | 2008-10-22 |
Ionic liquid‐H2O Resulting in a Highly Chemoselective Oxidation of Benzylic Alcohols in the Presence of Aliphatic Analogues Catalyzed by Immobilized TEMPO |
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| Ruijun HU,Ming LEI,Hegeng WEI,Yanguang WANG.Ionic liquid‐H2O Resulting in a Highly Chemoselective Oxidation of Benzylic Alcohols in the Presence of Aliphatic Analogues Catalyzed by Immobilized TEMPO[J].Chinese Journal of Chemistry,2009,27(3):587-592. |
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| Authors: | Ruijun HU Ming LEI Hegeng WEI Yanguang WANG |
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| Institution: | 1. Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China;2. Tel.: 0086‐0571‐87953816;3. Fax: 0086‐0571‐87953816 |
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| Abstract: | In ionic liquid 1‐butyl‐3‐methylimidazolium hexafluorophosphate (bmim]PF6])‐H2O, a highly chemoselective oxidation of benzylic alcohols in the presence of aliphatic ones to the corresponding hydroxyl benzyl aldehydes and ketones was allowed in high yields using N‐chlorosuccinimide (NCS)/NaBr/IL‐TEMPO (ionic liquid immobilized 2,2,6,6‐tetramethylpiperidine‐1‐oxyl) as a facile and effective catalytic oxidation system. The medium, bmim]PF6], together with the catalyst IL‐TEMPO could be easily recycled for ten runs without any influence on the efficacy of the reaction in terms of yield and selectivity of the product. |
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| Keywords: | chemoselective oxidation benzylic‐aliphatic diol hydroxyl benzyl aldehyde and ketone TEMPO ionic liquid |
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