Indium triflate-catalyzed vinylation of beta-ketoesters with acetylene gas |
| |
| Authors: | Nakamura Masaharu Endo Kohei Nakamura Eiichi |
| |
| Affiliation: | Department of Chemistry, The University of Tokyo, Hongo, Bunkyo-ku, Japan. |
| |
| Abstract: | [reaction: see text]. An In(OTf)(3)-catalyzed addition of a beta-ketoester to acetylene in the presence of molecular sieves produces a alpha-vinylated ketoester in good to excellent yield. The vinylation reaction proceeds without any loss of elements in starting molecules under solvent-free conditions and allows the use of welding-grade acetylene, providing a practical method for synthetic utilization of acetylene gas. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
