Di-carboxylic acid cross-linking interactions improves thermal stability and mechanical strength of reconstituted type I collagen |
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Authors: | Tapas Mitra G Sailakshmi A Gnanamani A B Mandal |
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Institution: | (1) Microbiology Division, Central Leather Research Institute (Council of Scientific and Industrial Research), Adyar, Chennai, 600020, Tamil Nadu, India;(2) Chemical Laboratory, Central Leather Research Institute (Council of Scientific and Industrial Research), Adyar, Chennai, 600020, Tamil Nadu, India; |
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Abstract: | This study emphasizes, cross-linking potential of a simple di-carboxylic acid, namely, oxalic acid with type I collagen for
the preparation of collagen based biomaterial for clinical applications. Further the study discusses the characteristics features
of the cross-linked material in comparison with the standard cross-linker. In addition, the study also demonstrates the role
of ionic interactions in providing the thermal stability and tensile strength to the cross-linked biopolymer material. Type
I collagen from rat tail tendon treated with oxalic acid at optimized concentrations provided a biopolymer material without
changing the triple helical pattern of collagen (CD spectrum) and also with 6–7 fold increase in tensile strength than native
collagen. FTIR spectral details demonstrate the ionic interactions between collagen and oxalic acid. Thermal stability analyses
of oxalic acid cross-linked biopolymer revealed, high thermal stability compared to materials of glutaraldehyde cross-linked.
The results of the study suggest oxalic acid as a suitable cross-linker for collagen and it cross-link with collagen through
ionic interactions. |
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