Analytical and radioanalytical quality control of purity and stability of radiopharmaceutical compound [186gRe]Re-HEDP for bone metastases pain palliation |
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| Authors: | D Bagatti M C Cantone A Giussani S Ridone C Birattari M L Bonardi F Groppi A Martinotti S Morzenti M Gallorini E Rizzio |
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| Institution: | (1) Universitá degli Studi di Milano, Department of Physics, Section of Medical Physics, Via Celoria 16, I-20133 Milano, Italy;(2) Universitá degli Studi di Milano, Department of Physics, Section of Medical Physics, Via Celoria 16, I-20133 Milano, Italy;(3) Universitá degli Studi di Milano, Department of Physics, Section of Medical Physics, Via Celoria 16, I-20133 Milano, Italy;(4) Universitá degli Studi di Milano, Department of Physics, Section of Medical Physics, Via Celoria 16, I-20133 Milano, Italy;(5) Radiochemistry Laboratory, LASA, Universitá degli Studi and INFN, Via F.lli Cervi 201, I-20090 Segrate, Milano, Italy;(6) Radiochemistry Laboratory, LASA, Universitá degli Studi and INFN, Via F.lli Cervi 201, I-20090 Segrate, Milano, Italy;(7) Radiochemistry Laboratory, LASA, Universitá degli Studi and INFN, Via F.lli Cervi 201, I-20090 Segrate, Milano, Italy;(8) Radiochemistry Laboratory, LASA, Universitá degli Studi and INFN, Via F.lli Cervi 201, I-20090 Segrate, Milano, Italy;(9) Radiochemistry Laboratory, LASA, Universitá degli Studi and INFN, Via F.lli Cervi 201, I-20090 Segrate, Milano, Italy;(10) Unit of Radiochemistry and Spectroscopy, CNR and University of Pavia, Via Taramelli 12, I-27100 Pavia, Italy;(11) Unit of Radiochemistry and Spectroscopy, CNR and University of Pavia, Via Taramelli 12, I-27100 Pavia, Italy |
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| Abstract: | Summary The nuclear properties of 186gRe make it a useful agent for radionuclide therapy and imaging. The coordination compound 186gRe]Re-HEDP has proved to be a successful bone seeking agent for palliation of metastatic bone pain. Chemical, radiochemical and radionuclidic purity of commercial radiopharmaceutical 186gRe]Re-HEDP have been checked by means by γ- and β-spectrometries, INAA and paper radio-chromatography. The results indicate a good radionuclidic purity, with levels of contamination from the short-lived 188Re well below the required specifications. After injection of the radiopharmaceutical, the radiochemical measurements conducted in vivo, on biological matrices, blood, plasma and urine, have shown that, entering the systemic circulation, 186gRe dissociates from the bis-phosphonate complex as hydrosoluble 186gRe]ReO4-, and the two chemical species follow different biokinetics. |
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