LASER-LIGHT INDUCED CHROMOSOME ABERRATIONS IN CHINESE HAMSTER CELLS |
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| Authors: | P. Virsik-Peuckert G. Hillrichs W. Neu D. Harder |
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| Affiliation: | Institute of Medical Physics and Biophysics, University of Göttingen, Goßlerstr. 10f, 3400 Göttingen, Germany;Laser-Laboratory Göttingen e.V., Im Hassel 21, 3400 Göttingen, Germany |
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| Abstract: | Wild-type Chinese hamster cells CHO Kl and their radiosensitive mutant xrs5 were irradiated at 308 nm, using light pulses of a XeCl excimer laser with total energy fluences of 0.1 kj/m2 to 4.08 kj/m2. Chromosome-type and chromatid-type chromosome aberrations have been observed at pulse irradiances of 2.5 × 107 W/m2 and 1.7 × 108 W/m2, indicating that in mammalian cells DNA double-strand breaks occur already in this irradiance range. The results obtained with laser irradiation are compared with X-ray irradiation. |
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