微波辐射下氧化N-烷基酰胺合成二酰亚胺

二酰亚胺是一个很有用的官能团, 它广泛存在于天然产物和有药物活性的分子中. 通过微波辐射条件合成它吸引了很多化学家的注意. 极性反应物可以吸收微波辐射, 化学家将微波应用于一些化学反应中. N-烷基酰胺(NH邻位有一个亚甲基CH₂)和N上没有取代的内酰胺可以被过氧化物和过渡金属盐氧化成二酰亚胺. 报道了在乙酸乙酯中过氧叔丁醇和乙酰丙酮锰(III)在微波条件(90 W, 5 min)下, 酰胺迅速、高选择性地、高产率地转变为二酰亚胺的方法.

Synthesis of Imide by Oxidation of N-Alkyl Amides under Microwave Irradiation

Imide group is an interesting functionality, due to its wide presence in the natural products and in the pharmacologically active compounds. This has attracted chemists’ attention as a target to be prepared by microwave irradiation. Since polar reactants can absorb the microwave irradiation, thus chemists can utilize the microwave oven for some organic reactions. N-Alkyl amides (with methylene CH₂ group adjacent to NH function of amide bond) and lactams, which need not be N-substituted, can be converted to imides by oxidation with a hydroperoxide and transition metal salts. It was reported that a rapid, selective and good yield conversion of the amides to imides by using t-buthyl hydroperoxide (t-BuOOH) and manganese(III) acetyl- acetonate Mn(acac)₃] in ethyl acetate under microwave irradiation (90 W, 5 min).