Total synthesis of (+)-phomactin a using a B-alkyl Suzuki macrocyclization |
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Authors: | Mohr Peter J Halcomb Randall L |
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Institution: | Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, USA. |
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Abstract: | A total synthesis of (+)-phomactin A is described using a B-alkyl Suzuki macrocyclization to incorporate the isolated trisubstituted olefin. This macrocyclization was accomplished with the sensitive hydrated furan ring in place. (R)-(+)-pulegone was used to establish the highly substituted cyclohexene core of the molecule. |
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