| 新疆汉族乳腺癌及乳腺良性病变组织中HPV16E6的半巢式PCR检测 |
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| 引用本文： | 洪波,曹玉文,付欣鸽,姚恩生,杨兰,李洪安,蒋金芳,梁伟华,郎健勇,李锋. 新疆汉族乳腺癌及乳腺良性病变组织中HPV16E6的半巢式PCR检测[J]. 石河子大学学报(自然科学版), 2009, 27(2) |
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| 作者姓名： | 洪波 曹玉文 付欣鸽 姚恩生 杨兰 李洪安 蒋金芳 梁伟华 郎健勇 李锋 |
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| 作者单位： | [1]石河子大学医学院,石河子832002 [2]汕头大学医学院第一附属医院,汕头515041 |
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| 摘 要： | 了解新疆地区汉族乳腺癌及乳腺良性病变组织中人类乳头状瘤病毒(Human papillomavirus,HPV)感染的情况,探讨乳腺癌及乳腺良性病变是否存在HPV16感染及HPV16感染与乳腺癌发病之间的关系.采用半巢式PCR(semi-nested polymerase chain reaction)技术检测80例乳腺癌及60例乳腺良性病变组织中HPV16感染的情况.结果 80例乳腺癌病例中,有22例(27.5%)检测到HPV16的DNA片断;60例乳腺良性病变中,有2例(3.3%)检测到HPV16的DNA序列,检测结果作χ2检验,χ2=14.10,P<0.001,差异有统计学意义.新疆汉族乳腺癌及乳腺良性病变存在HPV16感染,HPV16在乳腺癌的发病中发挥着一定的作用.
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| 关 键 词： | 乳腺癌 乳腺良性病变 半巢式PCR |
The Detection of HPV16E6 in Breast Cancer and Benign Breast Disease of Xinjiang Han Nationality by Semi-nested PCR |
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| HONG Bo,CAO Yuwen,YAO Eensheng,YANGLan,LI Hongan,JIANG Jinfang,LIANG Weihua,LANG Jianyong,LI Feng. The Detection of HPV16E6 in Breast Cancer and Benign Breast Disease of Xinjiang Han Nationality by Semi-nested PCR[J]. Journal of Shihezi University(Natural Science), 2009, 27(2) |
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| Authors: | HONG Bo CAO Yuwen YAO Eensheng YANGLan LI Hongan JIANG Jinfang LIANG Weihua LANG Jianyong LI Feng |
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| Affiliation: | 1School of Medicine;shihezi University;Shihezi 832002;China2First Afiliated Hospital;college of Medicine;Shantou University;Shantou;Guangdorg 515041;China |
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| Abstract: | To investigate the infection of the Human papillomavirus(HPV) in Xinjiang Breast Cancer and benign breast disease and explore the role of HPV16 in the pathogenesis of Breast Cancer.There are 80 patients and 60 controls detected.HPV16 DNA was detected by semi-nested Polymerase chain reaction.HPV16 DNA was detected in 22(27.5%) of 80 Breast Cancer and 2(3.3%) of 60 benign breast diseases,P<0.001.The difference is significant.The result of this study suggests that HPV16 may play an impotent role in the pathoge... |
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| Keywords: | HPV16E6 |
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