Synthesis of functional derivatives of isothiazole and isoxazole basing on (5-arylizoxazol-3-yl)- and (4,5-dichloroisothiazol-3-yl)arylmethanol |
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| Authors: | V. I. Potkin N. A. Bumagin A. V. Kletskov S. K. Petkevich P. V. Kurman |
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| Affiliation: | 1.Institute of Physical Organic Chemistry of Belarus National Academy of Sciences,Minsk,Belarus;2.Lomonosov Moscow State University,Moscow,Russia;3.Minsk Institute of Bioorganic Chemistry of Belarus National Academy of Sciences,Minsk,Belarus |
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| Abstract: | From (4,5-dichloroisothiazol-3-yl)phenylmethanol by Ritter reaction a substituted acetamide was synthesized that at hydrolysis with HCl afforded (4,5-dichloroisothiazol-3-yl)phenylmethylamine hydrochloride. By reaction of (5-arylisoxazol-3-yl)- and 4,5-dichloroisothiazol-3-yl)arylmethanol with thionyl chloride the corresponding (1,2-azol-3-yl)arylchloromethanes were obtained. At treatment with O- and N-nucleophiles chlorine atom in chloromethylеne fragment of obtained compounds was substituted by residues of benzylamine, morpholine, vanillin, and ethoxy group. |
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