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Synthesis of substituted 1-[2-(adamantan-1-yl)ethyl]piperidines |
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| Authors: | V A Shadrikova E V Golovin E A Kuznetsova M Yu Rostova Yu N Klimochkin |
| Abstract: | Quaternary 1-2-(adamantan-1-yl)ethyl]pyridinium bromides were reduced with sodium tetrahydridoborate in ethanol, and hydroarylation of the resulting 1-2-(adamantan-1-yl)ethyl]-1,2,3,6-tetrahydropyridines with benzene in trifluoromethanesulfonic acid afforded phenylpiperidines with preferentially equatorial orientation of the phenyl substituent. |
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