Identification of Tmem10/Opalin as a novel marker for oligodendrocytes using gene expression profiling |
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| Authors: | Angelika Kippert Katarina Trajkovic Dirk Fitzner Lennart Opitz Mikael Simons |
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| Institution: | 1.Centre for Biochemistry and Molecular Cell Biology,University of G?ttingen,G?ttingen,Germany;2.Max-Planck-Institute for Experimental Medicine,G?ttingen,Germany;3.Department of Neurology,University of G?ttingen,G?ttingen,Germany |
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| Abstract: | Background During the development of the central nervous system, oligodendrocytes generate large amounts of myelin, a multilayered insulating
membrane that ensheathes axons, thereby allowing the fast conduction of the action potential and maintaining axonal integrity.
Differentiation of oligodendrocytes to myelin-forming cells requires the downregulation of RhoA GTPase activity. |
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