Cell-permeable and biocompatible polymeric nanoparticles for apoptosis imaging |
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Authors: | Kim Kwangmeyung Lee Misu Park Hyungkyu Kim Jong-Ho Kim Sungwon Chung Hesson Choi Kuiwon Kim In-San Seong Baik L Kwon Ick Chan |
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Affiliation: | Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Haweolgog-Dong, Sungbook-Gu, Seoul 136-791, Korea. |
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Abstract: | Here, we report for the first time cell-permeable and biocompatible polymeric nanoparticles consisting of a polymer conjugated to a near-infrared (NIR) fluorescence (Cy5.5)-linked effector caspase-specific peptide. The close spatial proximity of the NIR fluorochromes in polymeric nanoparticles results in an autoquenched state, but polymer nanoparticles give rise to strong NIR fluorescence signal under apoptotic cells. Thus, the smart polymeric nanoparticle developed here is an attractive probe for real-time imaging of apoptosis in single cells. |
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