Isolation,structural determination and cytotoxic activity of two new ceramides from the root of <Emphasis Type="Italic">Isatis indigotica</Emphasis> |
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| Authors: | DongDong Sun WeiWei Dong Xiang Li HanQing Zhang |
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| Institution: | (1) Pharmaceutical College, Nanjing University of Chinese Medicine, Nanjing, 210046, China;(2) College of Chemistry and Chemical Engineering, Nanjing University of Technology, Nanjing, 210009, China;(3) Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, 210014, China |
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| Abstract: | Two new ceramides were isolated from the 95% EtOH extract of traditional Chinese medicinal plant Isatis indigotica. Their structures were elucidated as 1-O-β-D-glucopyranosyl-(2S, 3R)-N-(2′-hydroxype-ntacosanoyl)-octadeca-11E-sphingenine (1) and 1-O-β-D-glucopyranosyl-(2S,3R)-N-(2′-hydroxyhe xacosanoyl)-octadeca-11E-sphingenine (2) on the basis of spectroscopic data. Their cytotoxic effects were evaluated by using MTT method. |
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| Keywords: | Isatis indigotica ceramides cytotoxic activity |
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