| N-(4,6-二甲氧基嘧啶-2-基)-N'-磷酰基脲类衍生物的合成及生物活性 |
| |
| 引用本文： | 赵国锋,杨华铮,王玲秀. N-(4,6-二甲氧基嘧啶-2-基)-N'-磷酰基脲类衍生物的合成及生物活性[J]. 高等学校化学学报, 1998, 19(4): 555-559 |
| |
| 作者姓名： | 赵国锋 杨华铮 王玲秀 |
| |
| 作者单位： | 南开大学元素有机化学研究所, 元素有机化学国家重点实验室, 天津, 300071 |
| |
| 摘 要： | 利用二氯代磷酰基异氰酸酯与4,6-二甲氧基-2-氨基嘧啶的加成反应合成了中间体N-(4,6-二甲氧基嘧啶-2-基)-N'-二氯代磷酰基脲(Ⅰ).Ⅰ与2倍的醇或胺反应得到对称双取代磷酰基脲类化合物Ⅱa_Ⅱi;Ⅰ与1倍的胺反应得到氯代磷酰基脲类化合物Ⅲa_Ⅲe,再与1倍的醇反应则得到不对称双取代磷酰基脲类化合物Ⅳa_Ⅳg.生物活性测定结果表明,化合物Ⅱ、Ⅲ和Ⅳ均显示一定除草活性.
|
| 关 键 词： | 磷酰基脲 加成反应 合成 生物活性 |
| 收稿时间： | 1997-01-20 |
| 修稿时间： | 1997-01-20 |
The Synthesis and Biological Activity of N-(4,6-Dimethoxy-2-pyrimidinyl)-N'-phosphoryl Urea Derivatives |
| |
| ZHAO Guo-Feng,YANG Hua-Zheng,WANG Ling-Xiu. The Synthesis and Biological Activity of N-(4,6-Dimethoxy-2-pyrimidinyl)-N'-phosphoryl Urea Derivatives[J]. Chemical Research In Chinese Universities, 1998, 19(4): 555-559 |
| |
| Authors: | ZHAO Guo-Feng YANG Hua-Zheng WANG Ling-Xiu |
| |
| Affiliation: | Institute of Elemento Organic Chemistry, National Key Laboratory of Elemento Organic Chemistry, Nankai University, Tianjin, 300071 |
| |
| Abstract: | In this paper N-(4,6-dimethoxY-2-pyrimidinyl)-N'-dichloro-phosphoryl urea(Ⅰ) was synthesized by addition reaction of dichloro phosphoryl isocyanate with 4,6-dimethoxY-2-aminopyrimidine. Compound Ⅰ reacted with two equivalents of amines or alcohols to obtain symmetric disubstituted phosphoryl urea derivatives Ⅱa_Ⅱi, and reacted with one equivalent of amines to give monochlorophosphoryl ureas Ⅲa_Ⅲe which reacted with one equivalent of alcohols to obtain asymmetric disubstituted phosphoryl urea derivatives Ⅳa_ Ⅳg. The biological tests indicated that compounds Ⅱ, Ⅲ and Ⅳ showed herbicidal activities. |
| |
| Keywords: | Phosphoryl urea Addition reaction Synthesis Biological activity |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《高等学校化学学报》浏览原始摘要信息 |
|
点击此处可从《高等学校化学学报》下载全文 |
|
