| 双芳烃桥连salen配体的合成及其钛配合物在硅腈对醛的不对称加成反应中的应用 |
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| 引用本文： | 熊东路.双芳烃桥连salen配体的合成及其钛配合物在硅腈对醛的不对称加成反应中的应用[J].分子催化,2011,25(1):1-5. |
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| 作者姓名： | 熊东路 |
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| 作者单位： | 熊东路,XIONG Dong-lu(中国科学院兰州化学物理研究所,羰基合成与选择氧化国家重点实验室,甘肃,兰州,730000;中国科学院研究生院,北京,10039);王寿峰,孙伟,WANG Shou-feng,SUN Wei(中国科学院兰州化学物理研究所,羰基合成与选择氧化国家重点实验室,甘肃,兰州,730000) |
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| 摘 要： | 新型双芳烃桥连的salen钛配合物是一种高活性的催化三甲基硅腈对醛不对称加成反应的催化剂,底物与催化剂用量比率可达1 000:1.由(R,R)-1,2.环已二胺和3,5-二叔丁基水杨醛合成的催化剂4在催化三甲基硅腈对醛不对称加成反应中达到87%的对映选择性.
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| 关 键 词： | Salen Ti 双芳烃桥连 醛 三甲基硅腈 |
| 收稿时间： | 2010/10/14 0:00:00 |
| 修稿时间： | 2010/11/12 0:00:00 |
The Synthesis of Biaryl-bridged Salen Ligands and Their Application in Ti-Catalyzed Asymmetric Addition of Trimethylsilyl Cyanide to Aldehydes |
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| XIONG Dong-lu,WANG Shou-feng,SUN Wei.The Synthesis of Biaryl-bridged Salen Ligands and Their Application in Ti-Catalyzed Asymmetric Addition of Trimethylsilyl Cyanide to Aldehydes[J].Journal of Molecular Catalysis (China),2011,25(1):1-5. |
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| Authors: | XIONG Dong-lu WANG Shou-feng SUN Wei |
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| Institution: | XIONG Dong-lu1,2,WANG Shou-feng1,SUN Wei1(1.State Key Laboratory for Oxo Synthesis and Seletive Oxidation,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000,China,2.Graduate University of Chinese Academy of Science,Beijing 100049,China) |
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| Abstract: | The Biaryl-bridged Salen Ti complexes are a high active catalyst at substrate-to-catalyst ratios as high as 1 000:1 in the reaction of asymmetric addition of trimethylsilyl cyanide to aldehydes,and the optimal catalyst 4 derived from(R,R)-1,2-diaminocyclohexane and 3,5-di-tert-butyl-2-hydroxybenzaldehyde produces trimethylsilyl ethers of cyanohydrins with up to 87% enantiomeric excess at ambient temperature. |
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| Keywords: | Salen Ti |
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