Release of cationic drugs from loaded clay minerals |
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Authors: | I Fejér M Kata I Erös O Berkesi I Dékány |
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Institution: | Department of Pharmaceutical Technology, University of Szeged 6720 Szeged, E?tv?s u. 6, Hungary e-mail: fejeri@pharma.szote.u-szeged.hu Tel: +36-62-545571; Fax: +36-62-545571, HU Department of Physical Chemistry University of Szeged, 6720 Szeged Rerrich Béla tér 1, Hungary, HU Department of Colloid Chemistry University of Szeged, 6720 Szeged Rerrich Béla tér 1, Hungary, HU
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Abstract: | The adsorption of promethazine chloride 10-(2-dimethylammonium propyl) fenothiazine chloride] and buformin hydrochloride
(1-butylbiguanidine chloride) on montmorillonite was studied in previous work. The present article focuses on the desorption
of these molecules from their organocomplexes in a medium of artificial intestinal juice (pH 7.0 ± 0.1) at the temperature
of the human body (37 ± 0.5 °C). The desorption was investigated by kinetic studies, basal spacing measurements and Fourier
transform IR studies. Important quantitative differences were observed: buformin, which adsorbed in a monolayer coverage,
exhibited a very high desorption rate, whereas promethazine formed a pseudotrilayer arrangement and showed a lower dissolution
rate.
Received: 20 January 2001 Accepted: 8 March 2001 |
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Keywords: | Montmorillonite Promethazine chloride X-ray diffraction measurements Desorption Drug intercalation |
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