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Release of cationic drugs from loaded clay minerals
Authors:I Fejér  M Kata  I Erös  O Berkesi  I Dékány
Institution:Department of Pharmaceutical Technology, University of Szeged 6720 Szeged, E?tv?s u. 6, Hungary e-mail: fejeri@pharma.szote.u-szeged.hu Tel: +36-62-545571; Fax: +36-62-545571, HU
Department of Physical Chemistry University of Szeged, 6720 Szeged Rerrich Béla tér 1, Hungary, HU
Department of Colloid Chemistry University of Szeged, 6720 Szeged Rerrich Béla tér 1, Hungary, HU
Abstract:The adsorption of promethazine chloride 10-(2-dimethylammonium propyl) fenothiazine chloride] and buformin hydrochloride (1-butylbiguanidine chloride) on montmorillonite was studied in previous work. The present article focuses on the desorption of these molecules from their organocomplexes in a medium of artificial intestinal juice (pH 7.0 ± 0.1) at the temperature of the human body (37 ± 0.5 °C). The desorption was investigated by kinetic studies, basal spacing measurements and Fourier transform IR studies. Important quantitative differences were observed: buformin, which adsorbed in a monolayer coverage, exhibited a very high desorption rate, whereas promethazine formed a pseudotrilayer arrangement and showed a lower dissolution rate. Received: 20 January 2001 Accepted: 8 March 2001
Keywords:Montmorillonite  Promethazine chloride  X-ray diffraction measurements  Desorption  Drug intercalation
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